Review: progesterone or progestogens lead to a marginal reduction in premenstrual syndrome symptoms.

The author conducted an analysis of randomized, double blind, placebo-controlled studies of progesterone or progestins in women diagnosed with PMS.  Oral micronized progesterone and the progestogens MPA, norethisterone and dydrogesterone, all showed a marginal benefit over placebo in symptom reduction.

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Posted in Premenopause, Progesterone, Progestin

Progestogens used in menopause. Side effects, mood and quality of life.

Author: Sherwin BB. Publication Year: 1999 Citation: J Reprod Med 1999;44(2 Suppl):227-32. This review summarizes the effects of progesterone on mood and other brain functions. Progesterone receptors are present in many of the same areas of the brain as estrogen

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Posted in Brain, Estrogens, Menopausal Symptoms, Progesterone

Micronized progesterone: a new option for women’s health care.

Author: Wetzel W. Publication Year: 1999 Citation: Nurse Pract 1999;24(5):62-6, 71, 75-6. This paper discusses the use of micronized progesterone as a safe, effective, and well-tolerated therapy and reviews indications for use. It also includes case studies and issues of

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Posted in Menopausal Symptoms, Progesterone, Safety

Transdermal progesterone cream for vasomotor symptoms and postmenopausal bone loss.

Authors: Leonetti HB, Longo S, Anasti JN. Publication Year: 1999 Citation: Obstet Gynecol 1999;94(2):225-8. In this randomized controlled trial, 102 menopausal women were treated with topical progesterone (Pro-gest®, 20 mg daily) or placebo and monitored for 1 year. Improvement in

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Posted in Menopausal Symptoms, Progesterone

The relationship of longitudinal change in reproductive hormones and vasomotor symptoms during the menopausal transition.

Authors: Randolph JF, Sowers MF, Bondarenko I, Gold EB, Greendale GA, Bromberger JT, Brockwell SE, Matthews KA. Publication Year: 2005 Citation: J Clin Endocrinol Metab 2005;90(11):6106-12. Vasomotor symptoms are experienced by 65-76% of women going through menopause.  This study examined

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Posted in Androgens, Estrogens, Menopausal Symptoms, Progesterone

Natural progesterone and antihypertensive action.

Authors: Rylance PB, Brincat M, Lafferty K, De Trafford JC, Brincat S, Parsons V, Studd JW. Publication Year: 1985 Citation: Br Med J (Clin Res Ed) 1985;290(6461):13-4. In a placebo controlled, double blind crossover study, increasing doses of natural progesterone

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Posted in Cardiovascular, Menopausal Symptoms, Progesterone

Menopausal hormone replacement therapy with continuous daily oral micronized estradiol and progesterone.

Authors: Hargrove JT, Maxson WS, Wentz AC, Burnett LS. Publication Year: 1989 Citation: Obstet Gynecol 1989; 73( 4):606-12. Fifteen menopausal subjects were studied to determine the efficacy and safety of hormone replacement therapy with micronized estradiol (E2) and progesterone. Ten

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Posted in Cardiovascular, Estrogens, Formulations, Menopausal Symptoms, Progesterone

Low-dose progesterone therapy in oestrogenised postmenopausal women: effects on plasma lipids, lipoproteins and liver function parameters.

Authors: Bolaji II, Grimes H, Mortimer G, Tallon DF, Fottrell PF, O’Dwyer EM. Publication Year: 1993 Citation: Eur J Obstet Gynecol Reprod Biol 1993;48(1):61-8. This 12 month prospective, open, non-comparative study measured the effects of progesterone (oral micronized 100mg/day) paired

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Posted in Cardiovascular, Estrogens, Formulations, Menopausal Symptoms, Progesterone, Safety

Subfractions of high-density lipoprotein cholesterol during estrogen replacement therapy: A comparison between progestogens and natural progesterone.

Authors: Ottosson UB, Johansson BG, von Schoultz B. Publication Year: 1985 Citation: Am J Obstet Gynecol 1985;151(6):746-50. Fifty-eight postmenopausal women were followed with respect to subfractions of high-density lipoprotein during 3 cycles of unopposed estrogen. The women received either levonorgestrel,

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Posted in Cardiovascular, Estrogens, Formulations, Menopausal Symptoms, Progesterone, Progestin, Safety

Ovarian steroid protection against coronary artery hyperreactivity in rhesus monkeys.

Authors: Minshall RD, Stanczyk FZ, Miyagawa K, Uchida B, Axthelm M, Novy M, Hermsmeyer K. Publication Year: 1998 Citation: J Clin Endocrinol Metab 1998; 83(2):649-59. Medroxyprogesterone acetate, but not natural progesterone, negated the protective effects of estradiol against coronary artery

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Posted in Cardiovascular, Menopausal Symptoms, Progesterone, Progestin, Safety