Comparison of physical and emotional side effects of progesterone or medroxyprogesterone in early postmenopausal women.

Authors: Cummings JA, Brizendine L.

Publication Year: 2002

Citation: Menopause 2002;9(4):253-63.

Twenty-three early postmenopausal women were randomized to either medroxyprogesterone acetate (MPA) or oral micronized progesterone combined with conjugated equine estrogens (CEE) and followed for 91 days in a sequence of treatments. None of the hormone treatments had any noticeable effect on mood. Participants using MPA experienced more breast tenderness and bleeding than those using progesterone. This study debunks the belief that progesterone depresses mood in healthy individuals.