Effects of acute progesterone administration in healthy postmenopausal women and normally-cycling women.

Authors: de Wit H, Schmitt L, Purdy R, Hauger R.

Publication Year: 2001

Citation: Psychoneuroendocrinology 2001;26(7):697-710.

This randomized controlled study investigated the effects of acute progesterone administration (25, 50, 100 mg, intramuscularly, 1 dose/wk) on mood. Contrary to the investigators’ expectations, very few unwanted behavioral effects were noted, and only in the highest dose (100 mg) did women slightly increase their self-rating of “sluggishness”.