ProTECT: a randomized clinical trial of progesterone for acute traumatic brain injury.

Authors: Wright DW, Kellermann AL, Hertzberg VS, Clark PL, Frankel M, Goldstein FC, Salomone JP, Dent LL, Harris OA, Ander DS, Lowery DW, Patel MM, Denson DD, Gordon AB, Wald MM, Gupta S, Hoffman SW, Stein DG.
Publication Year:  2007
Citation: Ann Emerg Med. 2007;49(4):391-402, 402.e1-2.

A neuroprotective effect of progesterone was observed in this randomized, placebo-controlled trial of very high dose, intravenous progesterone therapy given for 3 days after acute traumatic brain injury.  Only 13% of the patients died within 30 days after injury in the progesterone group, compared with 30% of the placebo group, and the progesterone group was more likely to have a moderate to good functional outcome after 30 days than the placebo group.  Even at the extremely high dose used, no serious adverse events were seen with progesterone.

http://www.ncbi.nlm.nih.gov/pubmed/17011666