Distribution and metabolism of topically applied progesterone in a rat model.

Authors: Waddell BJ, O’Leary PC.

Publication Year: 2002

Citation: J Steroid Biochem Mol Biol 2002; 80(4-5): 449-55.

Following topical application of a commercially available progesterone cream, concentrations of fat and water-soluble metabolites of progesterone were measured in various tissues (uterus, kidney, salivary gland, liver) as well as plasma and urine. The topically applied progesterone was demonstrated to be well absorbed and had distribution and metabolism patterns similar to that seen with intravascular progesterone delivery.