Effects of progesterone on the inflammatory response to brain injury in the rat.

Authors: Grossman KJ, Goss CW, Stein DG.

Publication Year: 2004

Citation: Brain Res. 2004;1008(1):29-39.

Progesterone has a known anti-inflammatory effect. In this study, male rats treated with progesterone (4 mg/kg) and/or vehicle, were examined with respect to cellular inflammatory response to frontal cortex injury on post-surgical days 1, 3, 5, 7 and 9. The treated mice suffered significantly less edema than untreated mice, as well as showed an increase in the accumulation of activated microglia, demonstrating a neuroprotective effect on the rat brain.