Efficacy of progesterone and progestogens in management of premenstrual syndrome: systematic review.

Authors: Wyatt K, Dimmock P, Jones P, Obhrai M, O’Brien S.

Publication Year: 2001

Citation: BMJ 2001;323(7316):776-80.

This systematic review of published studies of progesterone or progestogens for treatment of PMS found a small positive effect of oral micronized progesterone over placebo in the 3 trials that studied this.  No published studies of progesterone cream were found.  A statistically, but not clinically, significant improvement was seen with progestogen treatment.