Authors: Wyatt K, Dimmock P, Jones P, Obhrai M, O’Brien S.
Publication Year: 2001
Citation: BMJ 2001;323(7316):776-80.
This systematic review of published studies of progesterone or progestogens for treatment of PMS found a small positive effect of oral micronized progesterone over placebo in the 3 trials that studied this. No published studies of progesterone cream were found. A statistically, but not clinically, significant improvement was seen with progestogen treatment.