Luteal support after in-vitro fertilization: Crinone® 8%, a sustained release vaginal progesterone gel, versus Utrogestan, an oral micronized progesterone.

Authors: Pouly JL, Bassil S, Frydman R, Hedon B, Nicollet B, Prada Y, Antoine JM, Zambrano R, Donnez J.

Publication Year: 1996

Citation: Human Reprod 1996;11:2085-89.

90 mg of vaginal estrogen gel daily was compared to 300 mg oral progesterone daily in a randomized open-label trial of 283 IVF patients. Delivery rates, safety parameters, frequency of spontaneous abortion, ratio of newborn babies to embryo transfer were nearly identical for both groups. The oral progesterone group reported more drowsiness.

http://www.ncbi.nlm.nih.gov/pubmed/8943507