Natural vaginal progesterone is associated with minimal psychological side effects: a preliminary study.

Authors: Shantha S, Brooks-Gunn J, Locke RJ, Warren MP.

Publication Year: 2001

Citation: J Womens Health Gend Based Med 2001;10(10):991-7.

This 3 month, multicenter randomized study evaluated the psychological side effects of a vaginally applied progesterone gel in reproductive aged women treated for hypothalamic amenorrhea or premature ovarian failure. No differences were noted in psychometric measures as evaluated by the Hopkins Symptom Checklist. Natural progesterone in a vaginal gel can be an effective treatment for women requiring hormone therapy.

http://www.ncbi.nlm.nih.gov/pubmed/11788109