Oral administration of micronized natural progesterone in late human pregnancy. Effects on progesterone and estrogen concentrations in the plasma, placenta, and myometrium.

Authors: Ferre F, Uzan M, Janssens Y, Tanguy G, Jolivet A, Breuiller M, Sureau C, Cedard L.

Publication Year: 1984

Citation: Am J Obstet Gynecol 1984; 148(1): 26-34.

Levels of progesterone, 17 beta-estradiol, and estrone were measured in the plasma, in the placenta, and at different sites in myometrium following a single dose of micronized oral progesterone administered to 15 pregnant women immediately prior to elective cesarean section.  In comparison to a control group, progesterone levels in the treated women increased in the plasma and myometrium 150 minutes after administration. Placenta progesterone levels did not demonstrate any change. No change was seen in 17 beta-estradiol levels in the plasma or the myometrium, however placental levels were increased. Estrone levels were decreased in the myometrium and in the placenta, and unchanged in the plasma.