Pharmacokinetic comparison of progesterone capsules with a progesterone gel after vaginal administration.

Authors: Kleinstein J, Schlegelmilch R, Mazur D, Vens-Cappell B.

Publication Year: 2002

Citation: Arzneimittelforschung 2002; 52(8):615-21.

Twenty-four women participated in this randomized controlled, crossover study comparing the bioavailability and pharmacokinetics of a vaginal progesterone capsule (200 mg/dose) vs a progesterone vaginal gel (90 mg/dose). Both were well tolerated, and no differences were noted with respect to safety. The vaginal capsule delivered more progesterone, however peak concentrations between the two preparations didn’t differ.