Progesterone and the premenstrual syndrome: a double blind crossover trial.

Authors: Dennerstein L, Spencer-Gardner C, Gotts G, Brown JB, Smith MA, Burrows GD.

Publication Year: 1985

Citation: Br Med J (Clin Res Ed) 1985; 290(6482): 1617-21.

In this double-blind, placebo-controlled, randomized, crossover trial, oral micronized progesterone demonstrated effectiveness in alleviating premenstrual complaints. Twenty-three women completed a Beck, et al depression inventory, Moos’s menstrual distress questionnaire, Spielberger, et al state anxiety inventory, and daily symptom diary before and during each treatment. There was an overall benefit of treatment for all variables, except positive moods, restlessness, and interest in sex. For most parameters, maximum benefit was seen within the first month of treatment, demonstrating an effectiveness of progesterone as a viable treatment option for women with PMS.