Topical progesterone cream has antiproliferative effect on estrogen-stimulated endometrium.

Authors: Leonetti HB, Wilson KJ, Anasti JN.

Publication Year: 2003

Citation: Fertil Steril 2003;79(1):221-2

This randomized, controlled study involving 58 postmenopausal women demonstrated that topically applied progesterone cream (Pro-gest®) had an antiproliferative effect in postmenopausal women who had been given oral estrogens x 14 days prior to progesterone treatment. Treatment with topical progesterone did not differ in effects from vaginally applied progesterone (Crinone®), and both progesterone applications demonstrated a significant effect over placebo. Patients preferred the topical application of progesterone cream.