Authors: Whitehead MI, Fraser D, Schenkel L, Crook D, Stevenson JC.
Publication Year: 1990
Citation: Lancet 1990; 335(8685):310-2.
Sixteen estrogen-deficient women were evaluated on a course of transdermal estradiol and transdermal progestogen for five cycles. Regular withdrawal bleeding was noted in all but one patient. Fourteen endometrial biopsies were performed after the fifth cycle, with no evidence of endometrial hyperplasia.