Author: Lobo RA.
Citation: J Reprod Med 1999; 44(2 Suppl):148-52.
This review clearly elucidates what’s known about the differences in metabolism of various progestins as compared with endogenous or natural progesterone. Not only are there different pathways for metabolism, but the route of administration also has a significant effect. The physiologic and pathologic state of the patient further influences the metabolism, and there are measurable variations between patients. The authors also review the differences expressed by various tissues in metabolizing progestogens as well as the different biologic potencies of the various progestogens. Most importantly, the authors state the lack of knowledge about the synthetic progestins as compared to natural progesterone, which has a much better understood effect in the body.