Sleep in menopause: differential effects of two forms of hormone replacement therapy.

Authors: Montplaisir J, Lorrain J, Denesle R, Petit D.

Publication Year: 2001

Citation: Menopause 2001; 8(1):10-16.

This randomized clinical trial compared the effects of conjugated equine estrogen (CEE) and medroxyprogesterone acetate to CEE and oral micronized progesterone. Twenty-one postmenopausal women were studied in a sleep lab, with results demonstrating an improvement in subjective measures of menopausal symptoms and sleep in both groups. The group receiving natural progesterone had significantly improved sleep efficiency, whereas the medroxyprogesterone acetate group did not, suggesting that the former might better improve sleep in postmenopausal women.