Authors: Gillson GR, Zava DT.
Publication Year: 2003
Citation: Int J Pharm Compounding 2003;7(4):250-6.
This article discusses some fundamental aspects of safer hormone replacement therapy that may have been overlooked in the debate surrounding bioidentical versus synthetic hormones: Oral delivery of hormones is not optimal; application of hormones to the skin (transdermal application) has many important advantages; and synthetic progestins are not acceptable as a substitute for natural progesterone. The evidence for and principles behind these factors are presented.