A perspective on HRT for women: picking up the pieces after the Women’s Health Initiative trial – Part 1.

Authors: Gillson GR, Zava DT.

Publication Year: 2003

Citation: Int J Pharm Compounding 2003;7(4):250-6.

This article discusses some fundamental aspects of safer hormone replacement therapy that may have been overlooked in the debate surrounding bioidentical versus synthetic hormones:  Oral delivery of hormones is not optimal; application of hormones to the skin  (transdermal application) has many important advantages; and synthetic progestins are not acceptable as a substitute for natural progesterone. The evidence for and principles behind these factors are presented.