A perspective on HRT for women: picking up the pieces after the Women’s Health Initiative trial – Part 2.

Authors: Gillson GR, Zava DT.

Publication Year: 2003

Citation: Int J Pharm Compounding 2003;7(5):330-8.

The authors review clinical evidence for the benefits of bioidentical progesterone over synthetic progestins.  While both protect the uterine lining from proliferation caused by estrogens, progesterone has beneficial effects on cardiovascular health.  The synergy between progesterone and estradiol , each “turning on” the other’s receptors, has the added benefit of allowing the estradiol dosage to be reduced. Oral and transdermal dosing of bioidentical progesterone are discussed.