Cardiovascular effects of medroxyprogesterone acetate and progesterone: a case of mistaken identity?

Authors: Hermsmeyer RK, Thompson TL, Pohost GM, Kaski JC.

Publication Year: 2008

Citation: Nat Clin Pract Cardiovasc Med 2008;5(7):387-95.

The authors present the current state of knowledge about the cardiovascular effects of progesterone compared to medroxyprogesterone acetate (MPA).  They caution that the beneficial effects of natural progesterone on cardiovascular risk have been obscured by the negative results of large trials involving hormone therapy that included MPA, in which cardiac risk was seen to increase.  The review covers the evidence that natural progesterone actually improves cardiovascular function, and compares oral and transdermal delivery.