Comparison of the long-term effects of oral estriol with the effects of conjugated estrogen on serum lipid profile in early menopausal women.

Authors: Itoi H, Minakami H, Iwasaki R, Sato I.

Publication Year: 2000

Citation: Maturitas 2000;36(3):217-22.

This was a randomized comparison study with three arms: 2.0mg estriol + 2.5mg medroxyprogesterone (E3), 0.625mg conjugated estrogen + 2.5mg medroxyprogesterone (CE) and a vitamin D and Calcium combination (control), looking at changes in serum lipid profiles in early menopausal women. The sample size was 67 women. After 48 months on the randomized protocol, the serum lipid profiles showed that those in the E3 group decreased total cholesterol and triglycerides (-4.9 and – 6.7) compared to the control of (+5.4 and +6.1) and CE group of (-1.9 and +17.6). The E3 group showed less significant changes in HDL cholesterol and LDL cholesterol when compared to the CE protocol: E3 (+3.8 and -5.2), CE (+10.7 and -11.4), control (-3.6 and +11.8). The results show the improvement of serum lipid profiles in response to estrogen. The authors suggested that in women where bleeding has been a problem response to certain estrogen protocols, the low-dose estriol may be an alternative treatment for those at risk of cardiovascular disease.