Effect of intravaginal dehydroepiandrosterone (Prasterone) on libido and sexual dysfunction in postmenopausal women.

Authors: Labrie F, Archer D, Bouchard C, Fortier M, Cusan L, Gomez JL, Girard G, Baron M, Ayotte N, Moreau M, Dubé R, Côté I, Labrie C, Lavoie L, Berger L, Gilbert L, Martel C, Balser J.

Publication Year: 2009

Citation: Menopause 2009; 16(5):923-31.

This randomized, placebo-controlled, double-blind clinical trial looked at the effects on libido and sexual function of 3 doses of DHEA or placebo vaginal suppositories applied with an applicator daily at bedtime for 12 weeks in 216 postmenopausal women with vaginal dryness.  Potent beneficial effects were seen with all 3 DHEA doses in the 4 aspects of sexual function studied: sensation, lubrication, orgasm, and dryness during intercourse.  DHEA converts naturally to active estrogens and androgens in tissues, and these hormones produced the beneficial effects on sexual function without raising systemic hormone levels.