Part 3 – The science behind bioidentical hormone replacement therapy.

Author: Wepfer ST

Publication Year: 2002

Citation: Int J Pharm Compounding 2002;6(2):142-6

Differences between synthetic progestins and bioidentical progesterone in terms of their effects on breast cancer risk, estrogen dominance, and vasomotor symptoms are discussed.  The review also covers the use of testosterone for postmenopausal women who have androgen deficiency because of surgically induced menopause.  Androgen deficiency is also seen in women receiving estrogen replacement therapy, which reduces bioavailable testosterone because it increases levels of sex hormone binding globulin in the blood.  The author concludes that bioidentical hormones are more effective and safer than the synthetic alternatives, but hopes that large trials will soon be conducted to confirm their promising effects.