Percutaneous 17beta-estradiol gel for the treatment of vasomotor symptoms in postmenopausal women.

Authors: Archer DF, Estrogel Study Group

Publication Year: 2003

Citation: Menopause. 2003; 10(6):516-21.

The frequency of moderate-to-severe hot flashes was significantly reduced after once daily application of estradiol gel for 12 weeks, compared to placebo gel, in 221 postmenopausal women.   Two doses of estradiol gel were used: 1.25 g, containing 0.75 mg estradiol, and 2.5 g, containing 1.5 mg estradiol.  Both were effective and well tolerated, although the higher dose resulted in more estrogen-related adverse events.