Authors: Archer DF, Estrogel Study Group
Publication Year: 2003
Citation: Menopause. 2003; 10(6):516-21.
The frequency of moderate-to-severe hot flashes was significantly reduced after once daily application of estradiol gel for 12 weeks, compared to placebo gel, in 221 postmenopausal women. Two doses of estradiol gel were used: 1.25 g, containing 0.75 mg estradiol, and 2.5 g, containing 1.5 mg estradiol. Both were effective and well tolerated, although the higher dose resulted in more estrogen-related adverse events.