Progesterone as a neuroprotective factor in traumatic and ischemic brain injury.

Authors: Sayeed I, Stein DG.

Publication Year: 2009

Citation: Prog Brain Res. 2009;175:219-37.

This review describes the effectiveness of progesterone in the treatment of traumatic brain injury, and then focuses on its potential role in the treatment of ischemic stroke.  Progesterone and its natural metabolites act through numerous mechanisms to exert their neuroprotective activity, and these are described in the review.  The authors recommend testing progesterone in clinical trials as a compelling natural treatment for nervous system injuries such as traumatic brain injury and stroke.