Safety and efficacy of oestriol for symptoms of natural or surgically induced menopause.

Authors: Takahashi K, Okada M, Ozaki T, Kurioka H, Manabe A, Kanasaki H, Miyazaki K.

Publication Year: 2000

Citation: Hum Reprod 2000;15(5):1028-36.

The authors gave 2 mg/day oral estriol for one year to 53 postmenopausal women (aged 40-62).  None of the patients stopped treatment due to side effects; level of satisfaction with the treatment increased throughout the study, and averaged at 85% in naturally menopausal women and 93% in surgically menopausal women by the end of the year.  Menopausal symptoms were significantly reduced.  No distinctive effects on bone or lipid levels were seen.  The authors suggest that estriol is a good choice of HRT to reduce symptoms in women who are not susceptible to osteoporosis or coronary artery disease.