The effect of low dose micronized 17beta-estradiol on bone turnover, sex hormone levels, and side effects in older women: a randomized, double blind, placebo-controlled study.

Authors: Prestwood KM, Kenny AM, Unson C, Kulldorff M.

Publication Year: 2000

Citation: J Clin Endocrinol Metab 2000;85(12):4462-9.

This study determined that oral low-dose estrogen (0.25mg/day) had similar beneficial effects on bone health in elderly (mean age 75 years) postmenopausal women without the breast tenderness and bleeding associated with higher doses. Authors recommended the use of serum E2 levels as the guide for therapeutic effect at a range of 10-28 pg/L.

http://www.ncbi.nlm.nih.gov/pubmed/11134094