The effects of oral estriol on the endometrium in postmenopausal women.

Authors: Granberg S, Eurenius K, Lindgren R, Wilhelmsson L.

Publication Year: 2002

Citation: Maturitas 2002;42(2):149-56.

This study conducted endometrial evaluation using both transvaginal ultrasound (TVS) and histologic biopsy by Pipelle in postmenopausal women taking a low-dose oral estriol (1 or 2 mg daily) for a mean duration of 4.3 years. Mean endothelial thickness in the study group after one year was 3.0mm and in the control group was 2.4mm. There was a noted increase in atrophic vaginal epithelium in the control group. There was a noted increased incidence of endometrial polyps in the study group (14.1%) compared to the control group (2.9%) although this was not determined to be clinically significant.