The effects of transdermal estradiol in combination with oral norethisterone on lipoproteins, coagulation, and endothelial markers in postmenopausal women with Type 2 diabetes: a randomized, placebo-controlled study.

Authors: Perera M, Sattar N, Petrie JR, Hillier C, Small M, Connell JM, Lowe GD, Lumsden MA.

Publication Year: 2001

Citation: J Clin Endocrinol Metab 2001;86(3):1140-3.

This study showed that transdermal estradiol and oral norethisterone reduce plasma triglyceride and total cholesterol levels, factor VII activity and von Willebrand factor antigen levels in women with Type 2 diabetes without a concurrent change in adiposity or glycemic control. The authors suggest that this protocol might be of benefit for women at high risk of cardiovascular disease.