The physiologic role and use of estriol.

Author: Paoletti J

Publication Year: 2009

Citation: Int J Pharm Compounding 2009;13(4)270-275.

Estriol has an important physiological role in the prevention of breast cancer by balancing the effects of the stronger estrogens, estradiol and estrone, effectively acting as an anti-estrogen.  The author explains this phenomenon and explains a rationale for appropriate dosing of estriol relative to estradiol in bioidentical hormone replacement therapy.