Ultra low-dose micronized 17ß-estradiol and bone density and bone metabolism in older women: a randomized controlled trial.

Authors: Prestwood KM, Kenny AM, Kleppinger A, Kulldorff M

Publication Year: 2003

Citation: JAMA 2003; 290(8):1042-8.

This study of 0.25 mg/day oral estradiol versus placebo for 3 years in women over 65 years old (with 100 mg/day oral micronized progesterone in women with a uterus in both groups) found an increase in bone density in the estradiol group compared with placebo.

http://www.ncbi.nlm.nih.gov/pubmed/12941676