Estriol: safety and efficacy.

Author: Head KA.

Publication Year: 1998

Citation: Altern Med Rev 1998;3(2):101-13.

The author reviews research on estriol, particularly looking at its effectiveness in treating menopausal symptoms, and in protecting against osteoporosis and cardiovascular disease.  Estriol is a weaker estrogen than estradiol or estrone, and has been found to be effective in controlling symptoms such as hot flashes, insomnia, vaginal dryness, and frequent urinary tract infections.  Estriol was not shown to effectively prevent bone loss except in some Japanese studies, and the author speculates that the Japanese diet with its phytoestrogen content may have been a factor.  Estriol’s protective effect against cardiovascular disease has not been well studied.