Effects of progesterone and 18-methyl levonorgestrel on osteoblastic cells.

Authors: Liang M, Liao EY, Xu X, Luo XH, Xiao XH.

Publication Year: 2003

Citation: Endocr Res 2003;29(4):483-501.

The authors evaluated in this study the effects of progesterone (P4) and levonorgestrel (LNG) on markers of bone growth, utilizing normal human osteoblasts as well as the osteosarcoma cell line, MG-63. Their study found that, compared with placebo, both P4 and LNG increased the proliferation and differentiation of human osteoblasts through osteocalcin gene transcription.