Spinal bone loss and ovulatory disturbances.

Authors: Prior JC, Vigna YM, Schecter MI, Burgess AE.

Publication Year: 1990

Citation: N Engl J Med 1990; 323(18):1221-7.

A review of the available data indicates that progesterone acts to promote bone metabolism. It appears to be independent of estrogen by either acting directly at progesterone receptors, or indirectly through competition at glucocorticoid receptors in the osteoblasts.