Antiestrogen action of progesterone in breast tissue.

Authors: Mauvais-Jarvis P, Kuttenn F, Gompel A.

Publication Year: 1987

Citation: Horm Res 1987;28(2-4):212-8.

In a review of international literature on the cellular effects of progesterone on both normal breast cells and breast cancer cell lines, the authors conclude that most data indicate progesterone and progestins have an antiestrogenic effect on the breast, as reflected in the decrease in estradiol receptor content, the decrease in cell proliferation, and an increase in a marker of cell differentiation, 17 beta-hydroxysteroid activity, which is mediated by the progesterone receptor.