Influences of percutaneous administration of estradiol and progesterone on human breast epithelial cell cycle in vivo.

Authors: Chang KJ, Lee TT, Linares-Cruz G, Fournier S, de Lignieres B.

Publication Year: 1995

Citation: Fertil Steril 1995; 63(4):785-91.

The effect of transdermal estradiol (1.5 mg), transdermal progesterone (25 mg), and combined transdermal estradiol and progesterone (1.5 mg and 25 mg) on human breast epithelial cell cycles was evaluated in vivo. Results demonstrated that estradiol significantly increases cell proliferation, while progesterone significantly decreases cell replication below that observed with placebo. Transdermal progesterone was also shown to reduce estradiol-induced proliferation.