Prevention of coronary hyperreactivity in pre-atherogenic menopausal rhesus monkeys by transdermal progesterone.

Authors: Hermsmeyer RK, Mishra RG, Pavcnik D, Uchida B, Axthelm MK, Stanczyk FZ, Burry KA, Illingworth DR, Kaski JC, Nordt FJ.

Publication Year: 2004

Citation: Arterioscler Thromb Vasc Biol 2004;24(5):955-61.

Previous studies by Hermsmeyer, et al demonstrated a reduction of coronary reactivity in response to sub-physiological levels of progesterone in non-atherogenic monkeys. In this study, the authors sought to determine if transdermal progesterone cream conferred coronary vascular protection in surgically menopausal pre-atherosclerotic rhesus monkeys. Compared with monkeys receiving placebo cream (n= 5), treated monkeys (n= 7) experienced reduced Lipoprotein (a) levels, and an attenuation of coronary vasoconstriction, which was artificially stimulated by intracoronary serotonin plus U46619. Coronary hyperreactivity is a component of coronary artery disease and was demonstrated in this study to be prevented in pre-atherosclerotic primates by progesterone cream treatment.