Preserved forearm endothelial responses with acute exposure to progesterone: A randomized cross-over trial of 17-beta estradiol, progesterone, and 17-beta estradiol with progesterone in healthy menopausal women.

Authors: Mather KJ, Norman EG, Prior JC, Elliott TG. Publication Year: 2000 Citation: J Clin Endocrinol Metab 2000;85(12):4644-9. Regularly menstruating women enjoy relative protection from cardiovascular disease. Until recently, this has been attributed to the function of estrogen, despite the fact that progesterone is also present. This study evaluated the differing acute effects of 17-beta …

The effects of short-term medroxyprogesterone acetate and micronized progesterone on glucose metabolism and lipid profiles in patients with polycystic ovary syndrome: a prospective randomized study.

Authors: Bagis T, Gokcel A, Zeyneloglu HB, Tarim E, Kilicdag EB, Haydardedeoglu B. Publication Year: 2002 Citation: J Clin Endocrinol Metab 2002;87(10):4536-40. This randomized prospective study evaluated and compared the effects of ten days treatment with oral and vaginal micronized progesterone (MP) and medroxyprogesterone acetate (MPA) on glucose metabolism, lipid profiles, and hormonal parameters in …

Chronic treatment with progesterone but not medroxyprogesterone acetate restores the endothelial control of vascular tone in the mesenteric artery of ovariectomized rats.

Authors: Chataigneau T, Zerr M, Chataigneau M, Hudlett F, Hirn C, Pernot F, Schini-Kerth VB. Publication Year: 2004 Citation: Menopause 2004;11(3):255-63. This study helps explain the more beneficial effects on the cardiovascular system of progesterone compared with MPA because of its enhancement of the protective effects of endothelial cells on the arterial walls. http://www.ncbi.nlm.nih.gov/pubmed/15167304

Progestins and breast cancer.

Authors: Pasqualini JR, Paris J, Sitruk-Ware R, Chetrite G, Botella J. Publication Year: 1998 Citation: J Steroid Biochem Mol Biol 1998;65(1-6):225-35. This review article outlines the many functions of progestogens in hormone-dependent and independent breast cancer and suggests new clinical applications for their use in the treatment of breast cancer. http://www.ncbi.nlm.nih.gov/pubmed/9699877

Estradiol and progesterone regulate the proliferation of human breast epithelial cells.

Authors: Foidart JM, Colin C, Denoo X, Desreux J, Beliard A, Fournier S, de Lignieres B. Publication Year: 1998 Citation: Fertil Steril 1998;69(5):963-9. In this double-blind randomized study to evaluate the effects of estrogen and progesterone on normal breast cells, 40 postmenopausal women received daily topical application of a gel containing either placebo, estradiol, progesterone, …

Progesterone receptor activation – an alternative to SERMs in breast cancer.

Authors: Desreux J, Kebers F, Noel A, Francart D, Van Cauwenberge H, Heinen V, Thomas JL, Bernard AM, Paris J, Delansorne R, Foidart JM. Publication Year: 2000 Citation: Eur J Cancer 2000;36 Suppl 4:S90-1. This review emphasizes progesterone’s role in supporting healthy breast homeostasis and opposing the proliferative effects of estradiol in the breast, unlike …

Osteoporosis reversal; the role of progesterone.

Author: Lee JR. Publication Year: 1990 Citation: International Clinical Nutrition Review 1990;10(3):384-91. Transdermal progesterone supplementation with and without conjugated estrogens was evaluated in a clinical setting using 100 women aged 38 to 83 years. The average time from onset of menopause was 16 years. 63 women were followed for three years with dual photon absorptiometry. …