Prevention of endometrial hyperplasia by progesterone during long-term estradiol replacement: influence of bleeding pattern and secretory changes.

Authors: Moyer DL, de Lignieres B, Driguez P, Pez JP. Publication Year: 1993 Citation: Fertil Steril 1993;59(5):992-7. It is often presumed that progesterone levels must be high enough to induce endometrial bleeding by withdrawal in order to convey protection during estrogen replacement therapy. In this expanded observational study, the authors sought to determine the influence of withdrawal …

Transvaginal administration of progesterone.

Authors: Fanchin R, De Ziegler D, Bergeron C, Righini C, Torrisi C, Frydman R. Publication Year: 1997 Citation: Obstet Gynecol 1997;90(3):396-401. Three different doses of transvaginal progesterone gel were administered to 40 estrogen-deprived women aged 25-41 years. Estradiol was administered orally for 28 days, with progesterone added vaginally on alternate days from days 15-27. Plasma gonadotropins, E1, …

Prenatal progesterone and educational attainments.

Author: Dalton K. Publication Year: 1976 Citation: Br J Psychiatry 1976; 129:438-42. This study compares educational attainments of 34 children whose mothers received prenatal progesterone with 37 normal and 12 toxemic controls. Results at ages 17-24 showed that progesterone children were more likely to continue schooling after 16 years, a higher number left school with ‘O’ …

Oral administration of micronized natural progesterone in late human pregnancy. Effects on progesterone and estrogen concentrations in the plasma, placenta, and myometrium.

Authors: Ferre F, Uzan M, Janssens Y, Tanguy G, Jolivet A, Breuiller M, Sureau C, Cedard L. Publication Year: 1984 Citation: Am J Obstet Gynecol 1984; 148(1): 26-34. Levels of progesterone, 17 beta-estradiol, and estrone were measured in the plasma, in the placenta, and at different sites in myometrium following a single dose of micronized oral progesterone …

Progesterone and the premenstrual syndrome: a double blind crossover trial.

Authors: Dennerstein L, Spencer-Gardner C, Gotts G, Brown JB, Smith MA, Burrows GD. Publication Year: 1985 Citation: Br Med J (Clin Res Ed) 1985; 290(6482): 1617-21. In this double-blind, placebo-controlled, randomized, crossover trial, oral micronized progesterone demonstrated effectiveness in alleviating premenstrual complaints. Twenty-three women completed a Beck, et al depression inventory, Moos’s menstrual distress questionnaire, Spielberger, …

Oral micronized progesterone. Bioavailability pharmacokinetics, pharmacological and therapeutic implications–a review.

Authors: Sitruk-Ware R, Bricaire C, De Lignieres B, Yaneva H, Mauvais-Jarvis P. Publication Year: 1987 Citation: Contraception 1987; 36(4): 373-402. This paper reviews the effects and benefits of oral micronized progesterone. Progesterone exhibits anti-estrogenic effects, anti-androgenic effects, and anti-mineralocorticoid effects in addition to its progestational effects. No side effects have been reported for micronized progesterone with …

Luteal support after in-vitro fertilization: Crinone® 8%, a sustained release vaginal progesterone gel, versus Utrogestan, an oral micronized progesterone.

Authors: Pouly JL, Bassil S, Frydman R, Hedon B, Nicollet B, Prada Y, Antoine JM, Zambrano R, Donnez J. Publication Year: 1996 Citation: Human Reprod 1996;11:2085-89. 90 mg of vaginal estrogen gel daily was compared to 300 mg oral progesterone daily in a randomized open-label trial of 283 IVF patients. Delivery rates, safety parameters, frequency of spontaneous …

Micronized progesterone in the treatment of imminent necrosis of a myoma during pregnancy. Ultrasound changes during treatment.

Authors: Hajek Z, Uhlir M. Publication Year: 1999 Citation: Ceska Gynekol 1999;64(3):189-92. Progesterone has a role in increasing blood flow to the uterus during pregnancy. As such, these researchers studied the effect of progesterone treatment to resolve imminent necrosis of a myoma in two cases. Both resolved within several days following oral and vaginal doses of progesterone …

Preregistration study on the safety and contraceptive efficacy of a progesterone-releasing vaginal ring in Chilean nursing women.

Authors: Massai R, Miranda P, Valdes P, Lavín P, Zepeda A, Casado ME, Silva MA, Fetis G,Bravo C, Chandía O, Peralta O, Croxatto HB, Díaz S. Publication Year: 1999 Citation: Contraception 1999;60(1):9-14. In this long-term controlled study, the safety and efficacy of a progesterone-releasing vaginal contraceptive device was compared to that of the copper-T 380A IUD …

Serum sex steroids in premenopausal women and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC).

Authors: Kaaks R, Berrino F, Key T, Rinaldi S, Dossus L, Biessy C, Secreto G, Amiano P, Bingham S, Boeing H, Bueno de Mesquita HB, Chang-Claude J, Clavel-Chapelon F, Fournier A, et al. Publication Year: 2005 Citation: J Natl Cancer Inst 2005; 97:755-65. In this large multicenter study, higher serum progesterone levels were associated with a significant …