Micronized progesterone: a new option for women’s health care.

Author: Wetzel W. Publication Year: 1999 Citation: Nurse Pract 1999;24(5):62-6, 71, 75-6. This paper discusses the use of micronized progesterone as a safe, effective, and well-tolerated therapy and reviews indications for use. It also includes case studies and issues of patient compliance and the need for an individualized treatment plan for women receiving hormone therapy. …

Low-dose progesterone therapy in oestrogenised postmenopausal women: effects on plasma lipids, lipoproteins and liver function parameters.

Authors: Bolaji II, Grimes H, Mortimer G, Tallon DF, Fottrell PF, O’Dwyer EM. Publication Year: 1993 Citation: Eur J Obstet Gynecol Reprod Biol 1993;48(1):61-8. This 12 month prospective, open, non-comparative study measured the effects of progesterone (oral micronized 100mg/day) paired with 0.625 mg conjugated equine estrogens (CEE) and found progesterone had no adverse effects on …

Subfractions of high-density lipoprotein cholesterol during estrogen replacement therapy: A comparison between progestogens and natural progesterone.

Authors: Ottosson UB, Johansson BG, von Schoultz B. Publication Year: 1985 Citation: Am J Obstet Gynecol 1985;151(6):746-50. Fifty-eight postmenopausal women were followed with respect to subfractions of high-density lipoprotein during 3 cycles of unopposed estrogen. The women received either levonorgestrel, medroxyprogesterone acetate, or natural progesterone during the last ten days of the treatment period. Both …

Ovarian steroid protection against coronary artery hyperreactivity in rhesus monkeys.

Authors: Minshall RD, Stanczyk FZ, Miyagawa K, Uchida B, Axthelm M, Novy M, Hermsmeyer K. Publication Year: 1998 Citation: J Clin Endocrinol Metab 1998; 83(2):649-59. Medroxyprogesterone acetate, but not natural progesterone, negated the protective effects of estradiol against coronary artery hyperreactivity. http://www.ncbi.nlm.nih.gov/pubmed/9467588

Preserved forearm endothelial responses with acute exposure to progesterone: A randomized cross-over trial of 17-beta estradiol, progesterone, and 17-beta estradiol with progesterone in healthy menopausal women.

Authors: Mather KJ, Norman EG, Prior JC, Elliott TG. Publication Year: 2000 Citation: J Clin Endocrinol Metab 2000;85(12):4644-9. Regularly menstruating women enjoy relative protection from cardiovascular disease. Until recently, this has been attributed to the function of estrogen, despite the fact that progesterone is also present. This study evaluated the differing acute effects of 17-beta …

The effects of short-term medroxyprogesterone acetate and micronized progesterone on glucose metabolism and lipid profiles in patients with polycystic ovary syndrome: a prospective randomized study.

Authors: Bagis T, Gokcel A, Zeyneloglu HB, Tarim E, Kilicdag EB, Haydardedeoglu B. Publication Year: 2002 Citation: J Clin Endocrinol Metab 2002;87(10):4536-40. This randomized prospective study evaluated and compared the effects of ten days treatment with oral and vaginal micronized progesterone (MP) and medroxyprogesterone acetate (MPA) on glucose metabolism, lipid profiles, and hormonal parameters in …

Prevention of coronary hyperreactivity in pre-atherogenic menopausal rhesus monkeys by transdermal progesterone.

Authors: Hermsmeyer RK, Mishra RG, Pavcnik D, Uchida B, Axthelm MK, Stanczyk FZ, Burry KA, Illingworth DR, Kaski JC, Nordt FJ. Publication Year: 2004 Citation: Arterioscler Thromb Vasc Biol 2004;24(5):955-61. Previous studies by Hermsmeyer, et al demonstrated a reduction of coronary reactivity in response to sub-physiological levels of progesterone in non-atherogenic monkeys. In this study, …

Chronic treatment with progesterone but not medroxyprogesterone acetate restores the endothelial control of vascular tone in the mesenteric artery of ovariectomized rats.

Authors: Chataigneau T, Zerr M, Chataigneau M, Hudlett F, Hirn C, Pernot F, Schini-Kerth VB. Publication Year: 2004 Citation: Menopause 2004;11(3):255-63. This study helps explain the more beneficial effects on the cardiovascular system of progesterone compared with MPA because of its enhancement of the protective effects of endothelial cells on the arterial walls. http://www.ncbi.nlm.nih.gov/pubmed/15167304

The proliferation of normal breast tissue implanted into athymic nude mice is stimulated by estrogen, but not by progesterone.

Authors: Laidlaw IJ, Clarke RB, Howell A, Owen AW, Potten CS, Anderson E. Publication Year: 1995 Citation: Endocrinology 1995;136(1):164-71. Normal human breast tissue was implanted subcutaneously into athymic nude mice. The mice were then treated with estradiol or progesterone such that serum levels approximated those seen in normal menstruating women. Immunocytochemical measures were made of …