Serum progesterone and prognosis in operable breast cancer.

Authors: Mohr PE, Wang DY, Gregory WM, Richards MA, Fentiman IS. Publication Year: 1996 Citation: Br J Cancer 1996;73:1552-5. Higher blood levels of progesterone measured during surgical treatment of breast cancers were associated with significantly better survival, especially in women who were node-positive (P<0.01). There was no significant relationship between estradiol levels and survival. This …

Progestins and breast cancer.

Authors: Pasqualini JR, Paris J, Sitruk-Ware R, Chetrite G, Botella J. Publication Year: 1998 Citation: J Steroid Biochem Mol Biol 1998;65(1-6):225-35. This review article outlines the many functions of progestogens in hormone-dependent and independent breast cancer and suggests new clinical applications for their use in the treatment of breast cancer. http://www.ncbi.nlm.nih.gov/pubmed/9699877

Estradiol and progesterone regulate the proliferation of human breast epithelial cells.

Authors: Foidart JM, Colin C, Denoo X, Desreux J, Beliard A, Fournier S, de Lignieres B. Publication Year: 1998 Citation: Fertil Steril 1998;69(5):963-9. In this double-blind randomized study to evaluate the effects of estrogen and progesterone on normal breast cells, 40 postmenopausal women received daily topical application of a gel containing either placebo, estradiol, progesterone, …

Bcl-2, survivin and variant CD44 v7-v10 are downregulated and p53 is upregulated in breast cancer cells by progesterone: inhibition of cell growth and induction of apoptosis.

Authors: Formby B, Wiley TS. Publication Year: 1999 Citation: Mol Cell Biochem 1999;202(1-2):53-61. This study sought to elucidate the mechanism by which progesterone inhibits the proliferation of breast cancer cells. Utilizing breast cancer cell lines with and without progesterone receptors (T47-D and MDA-231, respectively) in vitro, the authors looked at apoptosis (programmed cell death) in …

Percutaneous progesterone use and risk of breast cancer: results from a French cohort study of premenopausal women with benign breast disease.

Authors: Plu-Bureau G, Le MG, Thalabard JC, Sitruk-Ware R, Mauvais-Jarvis P. Publication Year: 1999 Citation: Cancer Detect Prev 1999;23(4):290-6. This cohort study followed 1150 premenopausal French women diagnosed with benign breast disease. Topical progesterone cream, a common treatment for mastalgia in Europe, had been prescribed to 58% of the women. Follow-up accumulated 12,462 person-years. There …

Progesterone effect on cell growth, ultrastructural aspect and estradiol receptors of normal human breast epithelial (HBE) cells in culture.

Authors: Malet C, Spritzer P, Guillaumin D, Kuttenn F. Publication Year: 2000 Citation: J Steroid Biochem Mol Biol 2000; 73: 171-81. In a culture system, progesterone was found to have an inhibitory effect on breast cell growth. When given following estradiol (E2), it limited the stimulatory effect of E2 on cell growth. http://www.ncbi.nlm.nih.gov/pubmed/10925217