Natural progesterone, but not medroxyprogesterone acetate, enhances the beneficial effect of estrogen on exercise-induced myocardial ischemia in postmenopausal women.

Authors: Rosano GM, Webb CM, Chierchia S, Morgani GL, Gabraele M, Sarrel PM, de Ziegler D, Collins P. Publication Year: 2000 Citation: J Am Coll Cardiol 2000;36(7):2154-9. This randomized crossover study compared the effects of estradiol (E2) (2mg/day), estradiol + progesterone (P4) vaginal gel (2 mg/day + 90 mg on alternate days), and estradiol + …

The effects of short-term medroxyprogesterone acetate and micronized progesterone on glucose metabolism and lipid profiles in patients with polycystic ovary syndrome: a prospective randomized study.

Authors: Bagis T, Gokcel A, Zeyneloglu HB, Tarim E, Kilicdag EB, Haydardedeoglu B. Publication Year: 2002 Citation: J Clin Endocrinol Metab 2002;87(10):4536-40. This randomized prospective study evaluated and compared the effects of ten days treatment with oral and vaginal micronized progesterone (MP) and medroxyprogesterone acetate (MPA) on glucose metabolism, lipid profiles, and hormonal parameters in …

Double-blind controlled trial of progesterone vaginal cream treatment for cyclical mastodynia in women with benign breast disease.

Authors: Nappi C, Affinito P, Di Carlo C, Esposito G, Montemagno U. Publication Year: 1992 Citation: J Endocrinol Invest 1992;15(11):801-6. Eighty regularly menstruating women with mastodynia were studied to evaluate the clinical effectiveness of vaginally administered micronized progesterone. Subjects were randomly assigned to one of two groups, with all participating in a control cycle prior …

Absorption of micronized progesterone from a nonliquefying vaginal cream.

Authors: Kimzey LM, Gumowski J, Merriam GR, Grimes GJ Jr, Nelson LM. Publication Year: 1991 Citation: Fertil Steril 1991; 56(5):995-6. The pharmacokinetics are compared between orally administered micronized progesterone, and that administered through a vaginal cream. Oral progesterone is extensively metabolized prior to reaching the target tissues, and progesterone metabolites may comprise a significant amount of progesterone …