Absorption of micronized progesterone from a nonliquefying vaginal cream.

Authors: Kimzey LM, Gumowski J, Merriam GR, Grimes GJ Jr, Nelson LM.

Publication Year: 1991

Citation: Fertil Steril 1991; 56(5):995-6.

The pharmacokinetics are compared between orally administered micronized progesterone, and that administered through a vaginal cream. Oral progesterone is extensively metabolized prior to reaching the target tissues, and progesterone metabolites may comprise a significant amount of progesterone measured in the serum. When compared, vaginal application sustained progesterone levels over a longer period of time than orally administered progesterone.