Percutaneous absorption of progesterone in postmenopausal women treated with transdermal estrogen.

Authors: Burry KA, Patton PE, Hermsmeyer K.

Publication Year: 1999

Citation: Am J Obstet Gynecol 1999;180(6 Pt 1):1504-11.

This pilot study demonstrated a significant increase in serum progesterone levels in 6 women receiving topical progesterone cream (Pro-gest®; 30-60 mg P4/day) and 17beta estradiol (0.05mg patch). The absorption of progesterone via a topical cream correlated well with estrogen absorption (p< 0.001). They concluded that progesterone cream appeared to be a safe and effective route of application.