Salivary, but not serum or urinary levels of progesterone are elevated after topical application of progesterone cream to pre-and postmenopausal women.

Authors: O’Leary P, Feddema P, Chan K, Taranto M, Smith M, Evans S.

Publication Year: 2000

Citation: Clin Endocrinol (Oxf) 2000;53(5):615-20.

Absorption of progesterone as provided in a topical preparation of “natural” progesterone cream to 6 premenopausal and 6 postmenopausal women was demonstrated via salivary hormone levels. Salivary progesterone concentrations reached their peak 1-4 hrs after application. A five-fold increase in mean levels was seen in the premenopausal group. Serum progesterone levels were not significantly different from baseline in either group, and serum progesterone was not seen as an effective measure of absorption of topically applied progesterone.