Transdermal progesterone cream for vasomotor symptoms and postmenopausal bone loss.

Authors: Leonetti HB, Longo S, Anasti JN.

Publication Year: 1999

Citation: Obstet Gynecol 1999;94(2):225-8.

In this randomized controlled trial, 102 menopausal women were treated with topical progesterone (Pro-gest®, 20 mg daily) or placebo and monitored for 1 year. Improvement in vasomotor symptoms was seen in 83% of the women in the treatment group who had experienced hot flashes, compared to 19% in the placebo group (p< .001). There was no difference noted in bone mineral densities between groups after one year. All women studied received a daily multivitamin and 1200 mg calcium.